Evolutionary biology of the innate immune response integrating behaviour, immunity and nanotechnology toward improving health in aquaculture. I approach this with an integrative suite of methods both experimental and theoretical spanning across the fields of behavioural ecology, evolution and immunity. This is underpinned by the application of state of the art genomic techniques including transcriptomics (RNA-Seq/microarray) and more recently whole genome sequencing supported within a proven bioinformatic strategy for assembly, annotation, analysis and network modelling. Throughout my career to date my major academic interest has become to explore how immunity has evolved and recently how environmental conditions, particularly temperature, modulate the plasticity of the immune response. To this end I have applied a multi-level approach reaching from genomics to cellular and system function to personality and population.
Boltana S, Sanhueza N, Donoso A, Aguilar A, Crespo D, Vergara D, Arriagada G, Morales-Lange B, Mercado L, Rey S, Tort L & MacKenzie S (2018) Brain, Behavior, and Immunity, 71, pp. 169-181. https://doi.org/10.1016/j.bbi.2018.03.023.
Torresen OK, Rise ML, Jin X, Star B, MacKenzie S, Jakobsen KS, Nederbragt AJ & Jentoft S (2016) An improved version of the Atlantic cod genome and advancements in functional genomics: implications for the future of cod farming. In: MacKenzie S, Jentoft S (ed.). Genomics in aquaculture, Cambridge, MA, USA: Elsevier, pp. 45-72.
Rey S, Huntingford FA, Boltana S, Vargas R, Knowles TG & MacKenzie S (2015) Proceedings of the Royal Society B: Biological Sciences, 282 (1819), Art. No.: 20152266. https://doi.org/10.1098/rspb.2015.2266.