Genomic tools for examining immune gene function in salmonid fish



Martin SAM, Collet B, MacKenzie S, Evensen O & Secombes CJ (2008) Genomic tools for examining immune gene function in salmonid fish. Reviews in Fisheries Science, 16 (Supplement 1), pp. 112-118.

The health status of farmed fish is central to the efficient production for harvest, as infection, either acute or chronic, will have serious effects on survival, growth, and quality of the final product. A correctly functioning immune system is vital to efficient aquaculture for both defense against invading pathogens and response to vaccines. The increase in sequence data for salmonid fish has allowed the development of tools to examine the immune response at both the transcriptional and the cellular level. This review will focus on identification of novel fish immune-related mRNA species by suppression subtractive hybridization, the expression pattern of mRNAs by transcriptome analysis (microarray), and the use of salmonid cell lines to examine the functional aspects of some key fish immune genes.

microarray; subtractive cloning; cell lines; cell engineering; immunology; salmon

Reviews in Fisheries Science: Volume 16, Issue Supplement 1

Publication date31/12/2008
PublisherTaylor and Francis

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Professor Simon MacKenzie

Professor Simon MacKenzie

Professor & Head of Inst of Aquaculture, Institute of Aquaculture