Citation Sarigiannis D, Gotti A, Karakitsios S, Asikainen A, Jantunen M, Semple S, Torfs R, de Brouwere K, Galea K & van Tongeren M (2011) A full chain mechanistic approach assessing health risks from multiple sources in indoor environments. In: 12th International Conference on Indoor Air Quality and Climate 2011, volume 3. 12th International Conference on Indoor Air Quality and Climate 2011, Austin, TX, USA, 05.06.2011-10.06.2011. Vermont, USA: International Society of Indoor Air Quality and Climate (ISIAQ), pp. 2199-2205. http://www.proceedings.com/18032.html
Abstract This study aims at developing a mechanistic model for assessing exposure and health risks posed by indoor air pollution. The modeling approach is implemented in a computational platform that allows the interconnection between several steps of the full-chain assessment through proper models and algorithms. The integrated modelling environment comprises four modules, as follows: Emissions-concentrations module, linking emission sources to indoor air concentrations, through IAQ modelling. Exposure module, linking the temporal variation of indoor air contamination to human exposure by taking into account time-activity, housing conditions, etc. Internal dosimetry module, linking the temporal variation of exposure to internal dose dynamics through Physiology Based PharmacoKinetic/Dynamic (PBPK/D) modelling. Health effects module, linking internal dose dynamics to possible health outcomes through Biology Based Dose Response (BBDR) models. The source-to-health outcome assessment is performed through a fully mechanistic approach, accounting for mixture effects assessment and biomonitoring data interpretation.
Sarigiannis, Dimosthenis; Gotti, Alberto; Karakitsios, Spyridon; Asikainen, Arja; Jantunen, Matti; Semple, Sean; Torfs, Rudi; de Brouwere, Katleen; Galea, Karen; van Tongeren, Martie