Age-related dataset on the mechanical properties and collagen fibril structure of tendons from a murine model

Citation

Goh KL, Holmes DF, Lu YH, Kadler KE & Purslow PP (2018) Age-related dataset on the mechanical properties and collagen fibril structure of tendons from a murine model. Scientific Data, 5, Art. No.: 180140. https://doi.org/10.1038/sdata.2018.140

Abstract
Connective tissues such as tendon, ligament and skin are biological fibre composites comprising collagen fibrils reinforcing the weak proteoglycan-rich ground substance in extracellular matrix (ECM). One of the hallmarks of ageing of connective tissues is the progressive and irreversible change in the tissue mechanical properties; this is often attributed to the underlying changes to the collagen fibril structure. This dataset represents a comprehensive screen of the mechanical properties and collagen fibril structure of tendon from the tails of young to old (i.e. 1.6–35.3 month-old) C57BL6/B mice. The mechanical portion consists of the load-displacement data, as well as the derived tensile properties; the structure data consists of transmission electron micrographs of collagen fibril cross section, as well as the derived cross-sectional parameters. This dataset will allow other researchers to develop and demonstrate the utility of innovative multiscale models and approaches of the extra-cellular and physiological events of ageing of current interest to ageing research, by reducing the current reliance on conducting new mammalian experiments.

Journal
Scientific Data: Volume 5