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Life-stage-associated remodelling of lipid metabolism regulation in Atlantic salmon

Gillard G, Harvey T, Gjuvsland A, Jin Y, Thomassen M, Lien S, Leaver M, Torgerson J, Hvidsten T, Vik JO & Sandve S (2018) Life-stage-associated remodelling of lipid metabolism regulation in Atlantic salmon. Molecular Ecology, 27 (5), pp. 1200-1213.

Atlantic salmon migrates from rivers to sea to feed, grow and develop gonads before returning to spawn in freshwater. The transition to marine habitats is associated with dramatic changes in the environment, including water salinity, exposure to pathogens and shift in dietary lipid availability. Many changes in physiology and metabolism occur across this life‐stage transition, but little is known about the molecular nature of these changes. Here, we use a long‐term feeding experiment to study transcriptional regulation of lipid metabolism in Atlantic salmon gut and liver in both fresh‐ and saltwater. We find that lipid metabolism becomes significantly less plastic to differences in dietary lipid composition when salmon transitions to saltwater and experiences increased dietary lipid availability. Expression of genes in liver relating to lipogenesis and lipid transport decreases overall and becomes less responsive to diet, while genes for lipid uptake in gut become more highly expressed. Finally, analyses of evolutionary consequences of the salmonid‐specific whole‐genome duplication on lipid metabolism reveal several pathways with significantly different (p

adaptation; fish; life stage; metabolism; transcriptomics

Molecular Ecology: Volume 27, Issue 5

Author(s)Gillard, Gareth; Harvey, Thomas; Gjuvsland, Arne; Jin, Yang; Thomassen, Magny; Lien, Sigbjorn; Leaver, Michael; Torgerson, Jacob; Hvidsten, Torgeir; Vik, Jon Olav; Sandve, Simen
Publication date31/03/2018
Publication date online12/02/2018
Date accepted by journal13/12/2017
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