Citation Leaver M, Davies J, George S, Burke MD & Raffaelli DG (1988) Induction of cytochrome p-450 monooxygenase activities in plaice by ‘model’ inducers and drilling muds. Marine Environmental Research, 24 (1-4), pp. 27-30. http://www.sciencedirect.com/science/article/pii/0141113688902486; https://doi.org/10.1016/0141-1136%2888%2990248-6
Abstract The hepatic cytochrome P-450-dependent monooxygenase system of the marine fish plaice has been characterised by i.p. injection with chemical inducing agents, followed by measurement of a variety of monooxygenase activities. The results suggest that more than one isozyme is present in these fish. The response to oil-based drilling fluids, a major contaminant of the North Sea, has also been examined and indicates that more than one isozyme is responsive to these products.