Citation Kille P, Kay J, Leaver M & George S (1992) Induction of piscine metallothionein as a primary response to heavy metal pollutants: applicability of new sensitive molecular probes. Aquatic Toxicology, 22 (4), pp. 279-286. http://www.sciencedirect.com/science/article/pii/0166445X9290045O; https://doi.org/10.1016/0166-445X%2892%2990045-O
Abstract Induction of metallothionein (MT) in piscine tissues is a primary response to heavy metals which is now being utilised for environmental monitoring. Recent molecular biological and immunological studies have revealed a strong structural conservation amongst fish MTs and clear differences from their mammalian and avian orthologues. Probes derived from these studies are now being utilised to investigate the functional role of MT in metal regulation and cytotoxicity.
Keywords Fish metallothioneins; mRNA; Amino acid sequences; Immunoassay; Cuitured cells; Heavy metals; Hormones
Journal Aquatic Toxicology: Volume 22, Issue 4
Kille, Peter; Kay, John; Leaver, Michael; George, Stephen