Article

FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males

Details

Citation

Scott RA, Bailey MES, Moran CN, Wilson RH, Fuku N, Tanaka M, Tsiokanos A, Jamurtas AZ, Grammatikaki E, Moschonis G, Manios Y & Pitsiladis YP (2010) FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. European Journal of Human Genetics, 18 (12), pp. 1339-1343. https://doi.org/10.1038/ejhg.2010.131

Abstract
Studies of the fat mass and obesity-associated (FTO) gene provide compelling evidence of genetic variation in the general population that influences fat levels and obesity risk. Studies of the interaction between genetic and environmental factors such as physical activity (PA) will promote the understanding of how lifestyle can modulate genetic contributions to obesity. In this study, we investigated the effect of FTO genotype, and interactions with PA or energy intake, in young children and adolescents. In all, 1–5-year-old children from the Growth, Exercise and Nutrition Epidemiological Study in preSchoolers (GENESIS) study (N=1980) and 11–18-year-old Greek adolescents (N=949) were measured for adiposity-related phenotypes and genotyped at the FTO single-nucleotide polymorphism (SNP) marker, rs17817449. Adolescents were classified as physically active or inactive based on self-reported levels of PA. In adolescents, FTO genotype influenced weight (P=0.001) and BMI (P=0.007). There was also a significant SNP*PA*gender interaction (P=0.028) on BMI, which reflected the association between FTO genotype and BMI in males (P=0.016), but not females (P=0.15), and significant SNP*PA interaction in males (P=0.007), but not females (P=0.74). The FTO genotype effect was more pronounced in inactive than active males. Inactive males homozygous for the G allele had a mean BMI 3 kg/m2 higher than T carriers (P=0.008). In the GENESIS study, no significant association between FTO genotype and adiposity was found. The present findings highlight PA as an important factor modifying the effect of FTO genotype.

Keywords
obesity; FTO; physical activity

Journal
European Journal of Human Genetics: Volume 18, Issue 12

StatusPublished
Publication date31/12/2010
URLhttp://hdl.handle.net/1893/12946
PublisherEuropean Society of Human Genetics
ISSN1018-4813

People (1)

People

Dr Colin Moran

Dr Colin Moran

Associate Professor, Sport