Graham B, Menzies J & Dutia MB (2009) Model of hyperpolarization dependent LTD in MVN neurons. CNS 2009: Annual Meeting of the Organization for Computational Neurosciences: Berlin, Germany, Berlin, Germany, 18.07.2009-23.07.2009. BMC Neuroscience, 10 (Supplement 1), pp. 205-205. https://doi.org/10.1186/1471-2202-10-S1-P205
Abstract Whole cell patch clamp recordings from rat MVN neurons have revealed a hyperpolarization dependent LTD at vestibular afferent synapses. The induction protocol consisted of a brief 20 ms membrane hyperpolarization (to mimic the time-course of IPSPs from Purkinje cells converging on the MVN neuron), paired with a single vestibular afferent stimulus which was applied at various times relative to the membrane hyperpolarization. The LTD of afferent synapses was observed when vestibular stimuli arrived from 20 to 40 ms after the onset of the hyperpolarization. Simulations of a compartmental model of a MVN type B neuron were used to study the ionic currents and calcium transients at synaptic locations on dendrites during the same stimulation protocols that resulted in LTD in the tissue slice preparations.