Apolipoprotein E polymorphism and neuropsychological outcome following subarachnoid haemorrhage


Morris PG, Wilson JTL, Dunn LT & Nicoll JAR (2004) Apolipoprotein E polymorphism and neuropsychological outcome following subarachnoid haemorrhage. Acta Neurologica Scandinavica, 109 (3), pp. 205-209.

Objectives- To investigate the association between APOE genotypeand cognitive and emotional outcome following spontaneoussubarachnoid haemorrhage (SAH). Materials and methods-Neuropsychological assessments were conducted with 70 SAHsurvivors derived from a consecutive series of neurosurgicaladmissions. Outcomes, including cognitive tests, health questionnairesand Glasgow Outcome Scale at a mean of 16 months after SAH, werecompared with presence or absence of the e4 allele. Results- There wasno evidence that SAH survivors possessing the e4 allele had pooreroutcome. The only suggestion of an association between the e4 alleleand outcome was in a subgroup of patients with a Fisher grade 4haemorrhage, although this trend did not reach statisticalsignificance. Conclusions- Overall, possession of the APOE e4 allele isnot significantly associated with neuropsychological outcomefollowing SAH. However, there may be an effect amongst those with aFisher grade 4 haemorrhage.

subarachnoid haemorrhage; SAH; stroke; apolipoprotein E; outcome; Fisher grade

Acta Neurologica Scandinavica: Volume 109, Issue 3

Publication date31/03/2004
Publication date online10/2003