Roque A, Turnbull J & Gomez-Gil B (1998) Delivery of bioencapsulated oxytetracycline to the marine shrimp Penaeus monodon. Journal of the World Aquaculture Society, 29 (2), pp. 249-251. https://doi.org/10.1111/j.1749-7345.1998.tb00984.x
Post larvae of shrimp Penaeus monodon were fed Artemia sp. enriched with oxytetracycline (OTC). The amounts of this antibiotic in the Artemia sp., the shrimp, and the water of the experimental system were measured by radial diffusion bioassay. The results indicated that 11% of the OTC was taken up by the Artemia sp. After 8 d of being fed OTC-enriched Artemia sp., the shrimp were found to contain 3.12 μg OTC/shrimp, which is twelve times greater than the average minimum inhibitory concentration (MIC) cited in the literature for sensitive strains of Vibrio spp. The recommended therapeutic dose for treatment of bacterial infections is four times the MIC.
Journal of the World Aquaculture Society: Volume 29, Issue 2