O'Carroll R & Bancroft J (1985) Androgens and aggression in man: A controlled case study. Aggressive Behavior, 11 (1), pp. 1-7. https://doi.org/10.1002/1098-2337%281985%2911%3A1%3C1%3A%3AAID-AB2480110102%3E3.0.CO%3B2-8
A controlled case study is reported of the behavioural effects of androgen treatment in an institutionalised hypogonadal mentally retarded male patient. This man was previously treated with intramuscular depot injections of testosterone esters; however, treatment had to be stopped as the androgens allegedly precipitated frequent bouts of violent behaviour. Using ratings of behaviour by hostel staff, replacement therapy was restarted using the new orally effective androgen, testosterone undecanoate (TU). Gradually increasing the replacement dose of TU in a double-blind fashion resulted in no stimulatory effect on aggressive behaviour. Possible reasons for the differential behavioural response to the two androgen preparations are presented.
Aggressive Behavior: Volume 11, Issue 1