Neuropsychiatric syndromes in dementia - Results from the European Alzheimer Disease Consortium: Part I

Citation

Aalten P, Verhey FRJ, Boziki M, Bullock RA, Byrne EJ, Camus V, Caputo M, Collins D, De Deyn PP, Elina K, Frisoni G, Girtler N, Holmes C, Hurt C & Reynish E (2007) Neuropsychiatric syndromes in dementia - Results from the European Alzheimer Disease Consortium: Part I. Dementia and Geriatric Cognitive Disorders, 24 (6), pp. 457-463. https://doi.org/10.1159/000110738

Abstract
Background/Aims: The aim of this study was to identify neuropsychiatric subsyndromes of the Neuropsychiatric Inventory in a large sample of outpatients with Alzheimer's disease (AD). Methods: Cross-sectional data of 2,354 patients with AD from 12 centres from the European Alzheimer's Disease Consortium were collected. Principal component analysis was used for factor analysis. Results: The results showed the presence of 4 neuropsychiatric subsyndromes: hyperactivity, psychosis, affective symptoms and apathy. The subsyndrome apathy was the most common, occurring in almost 65% of the patients. Conclusion: This large study has provided additional robust evidence for the existence of neuropsychiatric subsyndromes in AD.

Keywords
neuropsychiatric syndromes; neuropsychiatric inventory; factor analysis; Alzheimer's disease; dementia; subsyndromes

Notes
Additional co-authors: Marriott A, Mecocci P, Nobili F, Ousset PJ, Salmon E, Tsolaki M, Vellas B, Robert PH

Journal
Dementia and Geriatric Cognitive Disorders: Volume 24, Issue 6