Citation Graham B, Wong AYC & Forsythe ID (2004) A multi-component model of depression at the calyx of Held. Neurocomputing, 58-60, pp. 449-454. https://doi.org/10.1016/j.neucom.2004.01.080
Abstract An average-response model of depression at the calyx of Held, a giant glutamatergic synapse in the mammalian auditory pathway, is presented. The model is fit to experimentally recorded EPSC amplitudes resulting from 10 to 100 Hz presynaptic stimulation for 1$. This data exhibits a strong depression of the EPSC amplitude. The model best fits the time course and magnitude of depression when significant postsynaptic receptor desensitisation and vesicle replenishment from a small, depleting reserve pool were included.
Keywords calyx of Held; synaptic transmission; synaptic depression