Automated and miniaturized detection of biological threats with a centrifugal microfluidic system

Citation

Mark D, van Oordt T, Strohmeier O, Roth G, Drexler J, Eberhard M, Niedrig M, Patel P, Zgaga-Griesz A, Bessler WG, Weidmann M, Hufert FT, Zengerle R & von Stetten F (2012) Automated and miniaturized detection of biological threats with a centrifugal microfluidic system. In: Cullum B & McLamore E (eds.) Smart Biomedical and Physiological Sensor Technology IX. Proceedings of SPIE, 8367. Smart Biomedical and Physiological Sensor Technology IX, Baltimore, MD, USA, 23.04.2012-23.04.2012. SPIE, p. 83670E. http://spie.org/x648.html?product_id=902831; https://doi.org/10.1117/12.919933

Abstract
The world's growing mobility, mass tourism, and the threat of terrorism increase the risk of the fast spread of infectious microorganisms and toxins. Today's procedures for pathogen detection involve complex stationary devices, and are often too time consuming for a rapid and effective response. Therefore a robust and mobile diagnostic system is required. We present a microstructured LabDisk which performs complex biochemical analyses together with a mobile centrifugal microfluidic device which processes the LabDisk. This portable system will allow fully automated and rapid detection of biological threats at the point-of-need.© (2012) COPYRIGHT Society of Photo-Optical Instrumentation Engineers (SPIE). Downloading of the abstract is permitted for personal use only.

Keywords
Lab-on-a-chip; point-of-need; microfluidics; pathogen detection; genotyping; PCR; immunoassays