The PRECIS-2 tool: Designing trials that are fit for purpose

Citation

Loudon K, Treweek S, Sullivan F, Donnan PT, Thorpe KE & Zwarenstein M (2015) The PRECIS-2 tool: Designing trials that are fit for purpose. BMJ, 350, Art. No.: h2147. https://doi.org/10.1136/bmj.h2147

Abstract
PRECIS is a tool to help trialists make design decisions consistent with the intended purpose of their trial. This paper gives guidance on how to use an improved, validated version, PRECIS-2, which has been developed with the help of over 80 international trialists, clinicians, and policymakers. Keeping the original simple wheel format, PRECIS-2 has nine domains-eligibility criteria, recruitment, setting, organisation, flexibility (delivery), flexibility (adherence), follow-up, primary outcome, and primary analysis-scored from 1 (very explanatory) to 5 (very pragmatic) to facilitate domain discussion and consensus. It is hoped PRECIS-2 will be valuable in supporting the explicit matching of design decisions to how the trial results are intended to be used

Journal
BMJ: Volume 350