Inhibitory control of site-specific synaptic plasticity in a model CA1 pyramidal neuron

Citation

Saudargiene A & Graham B (2015) Inhibitory control of site-specific synaptic plasticity in a model CA1 pyramidal neuron. Biosystems, 130, pp. 37-50. https://doi.org/10.1016/j.biosystems.2015.03.001

Abstract
A computational model of a biochemical network underlying synaptic plasticity is combined with simulated on-going electrical activity in a model of a hippocampal pyramidal neuron to study the impact of synapse location and inhibition on synaptic plasticity. The simulated pyramidal neuron is activated by the realistic stimulation protocol of causal and anticausal spike pairings of presynaptic and postsynaptic action potentials in the presence and absence of spatially targeted inhibition provided by basket, bistratified and oriens-lacunosum moleculare (OLM) interneurons. The resulting Spike-timing-dependent plasticity (STDP) curves depend strongly on the number of pairing repetitions, the synapse location and the timing and strength of inhibition.

Keywords
Spike-timing-dependent plasticity; CA1 pyramidal neuron; Dendritic spike; Inhibitory interneurons

Journal
Biosystems: Volume 130

People

Professor Bruce Graham

Emeritus Professor, Computing Science