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Article

Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data

Citation
Clague F, Mercer SW, McLean G, Reynish E & Guthrie B (2017) Comorbidity and polypharmacy in people with dementia: insights from a large, population-based cross-sectional analysis of primary care data. Age and Ageing, 46 (1), pp. 33-39. https://doi.org/10.1093/ageing/afw176

Abstract
Background  the care of older people with dementia is often complicated by physical comorbidity and polypharmacy, but the extent and patterns of these have not been well described. This paper reports analysis of these factors within a large, cross-sectional primary care data set.  Methods  data were extracted for 291,169 people aged 65 years or older registered with 314 general practices in the UK, of whom 10,258 had an electronically recorded dementia diagnosis. Differences in the number and type of 32 physical conditions and the number of repeat prescriptions in those with and without dementia were examined. Age–gender standardised rates were used to calculate odds ratios (ORs) of physical comorbidity and polypharmacy.  Results  people with dementia, after controlling for age and sex, had on average more physical conditions than controls (mean number of conditions 2.9 versus 2.4;P

Keywords
older people; comorbidity; multi-morbidity; dementia; Alzheimer's disease; polypharmacy

Journal
Age and Ageing: Volume 46, Issue 1

StatusPublished
Author(s)Clague, Fiona; Mercer, Stewart W; McLean, Gary; Reynish, Emma; Guthrie, Bruce
Publication date31/01/2017
Publication date online13/10/2016
Date accepted by journal13/09/2016
URLhttp://hdl.handle.net/1893/25863
PublisherOxford University Press
ISSN0002-0729
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