The case for model-informed vaccine development

Citation

PF Bai J, Beigmohammadi F, Craig M, Dalton M, Desikan R, Easlick T, Gazeau S, Heffernan J, Kirpichnikova A, Padmanabhan P, Sachs JR, Sher A, Skibinski D & Smith AM (2026) The case for model-informed vaccine development. Vaccine, 92, Art. No.: 128780. https://doi.org/10.1016/j.vaccine.2026.128780

Abstract
This perspective paper illustrates how model-informed vaccine development (MIVD) impacts vaccine discovery and development decisions, saving time and resources. It discusses the benefits of mechanistic and other mathematical models within MIVD. We outline key applications, opportunities, challenges, and future steps for MIVD as a call for the continued integration of mathematical modelling during vaccine development.

Keywords
Model-informed vaccine development; MIVD; Quantitative systems pharmacology/toxicology; QSP/T; Mathematical models

Journal
Vaccine: Volume 92