Commentary

Navigating space in the mammalian brain

Citation

Wood E & Dudchenko P (2021) Navigating space in the mammalian brain. Science, 372 (6545), pp. 913-914. https://doi.org/10.1126/science.abi9663

Abstract
How does the brain represent the world and allow spatial navigation? One mechanism is hippocampal place cells—neurons that fire according to where an animal is in its environment. Different place cells fire according to different locations, and together they are thought to provide a cognitive map that supports spatial navigation and memory (1). Place cells have been described in a range of mammalian species, including mice, bats, marmosets, and humans. However, most studies have used rats in small enclosures or mazes. Thus, it is unknown how such representations might underpin larger-scale, real-world navigation. On page 933 of this issue, Eliav et al. (2) show that in bats flying in a large (200-m-long) enclosure, most place cells fire in several different locations and with varying spatial scales. Such multiscale representations are likely the most efficient way for a finite number of neurons to encode large distances.

Journal
Science: Volume 372, Issue 6545

StatusPublished
Publication date28/05/2021
Publication date online28/05/2021
Date accepted by journal14/05/2021
URLhttp://hdl.handle.net/1893/32984
ISSN0036-8075
eISSN1095-9203