Book Chapter

The Vaccination Model in Psychoneuroimmunology Research: A Review



Whittaker AC (2018) The Vaccination Model in Psychoneuroimmunology Research: A Review. In: Yan Q (ed.) Psychoneuroimmunology: Methods and Protocols. Methods in Molecular Biology, 1781. New York: Springer, pp. 309-326.

This chapter explores the reasoning behind using the vaccination model to examine the influence of psychosocial factors on immunity. It then briefly discusses the mechanics of the vaccination response and the protocols used in psychoneuroimmunology vaccine research, before giving examples from the research literature of the studies examining relationships such as the association between stress and vaccination response. It also explores the ways the vaccination model can be used to answer key questions in psychoneuroimmunology, such as the following: “Does it matter when stressful life events occur relative to when the vaccine is received?” “What are the effects of prior exposure to the antigen?” “Do other psychosocial factors influence vaccine response besides stress?” Finally, it briefly considers the mechanisms underlying psychosocial factors and vaccination response associations and the future research needed to understand these better, and indeed to use current and future knowledge to improve and enhance vaccine responses in key at-risk populations.

Caregiving; Influenza; Interventions; Social support; Stress; Vaccine

FundersUniversity of Birmingham
Title of seriesMethods in Molecular Biology
Number in series1781
Publication date31/12/2018
Publication date online29/04/2018
Place of publicationNew York
ISSN of series1064-3745

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Professor Anna Whittaker

Professor Anna Whittaker

Professor of Behavioural Medicine, Sport