Article

Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study

Details

Citation

Mikolic A, Polinder S, Steyerberg EW, Retel Helmrich IRA, Giacino J, Maas A, van der Naalt J, Voormolen DC, von Steinbuechel N, Wilson L, Lingsma HF, van Klaveren D & CENTER-TBI Participants and Investigators (2020) Prediction of Global Functional Outcome and Post-Concussive Symptoms after Mild Traumatic Brain Injury: External Validation of Prognostic Models in the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) Study. Journal of Neurotrauma, 38 (2), pp. 196-209. https://doi.org/10.1089/neu.2020.7074

Abstract
The majority of patients with traumatic brain injury (TBI) are categorized as mild according to a baseline Glasgow Coma Scale (GCS) score of 13 to 15. Prognostic models that were developed to predict functional outcome and persistent post-concussive symptoms (PPCS) after mild TBI have rarely been externally validated. We aimed to identify validate existing models predicting 3 to 12-month Glasgow Outcome Scale Extended (GOSE) or PPCS in adults with mild TBI. We analyzed data from the Collaborative European NeuroTrauma Effectiveness Research in Traumatic Brain Injury (CENTER-TBI) project, which included 2862 adults with mild TBI, with 6-month GOSE available for 2374, and the Rivermead Post-concussion Symptom Questionnaire (RPQ) for 1605 participants. Model performance was evaluated based on calibration (graphically and characterized by slope and intercept) and discrimination (c-index). We validated five published models for 6-month GOSE and three for 6-month PPCS scores. The models used different cutoffs for outcome and some included symptoms measured 2 weeks post-injury. Discriminative ability varied substantially (C- index between 0.58 and 0.79). The models developed in the CRASH trial for prediction of GOSE

Keywords
external validation; mild traumatic brain injury; prognostic model; Glasgow Outcome Scale Extended; post-concussive symptoms

Journal
Journal of Neurotrauma: Volume 38, Issue 2

StatusPublished
FundersEuropean Commission (Horizon 2020)
Publication date31/12/2020
Publication date online25/09/2020
Date accepted by journal25/09/2020
URLhttp://hdl.handle.net/1893/31782
ISSN0897-7151
eISSN1557-9042

People (1)

People

Professor Lindsay Wilson

Professor Lindsay Wilson

Emeritus Professor, Psychology