Cardiovascular activity and the antibody response to vaccination



Phillips AC, Carroll D, Burns VE & Drayson M (2009) Cardiovascular activity and the antibody response to vaccination. Journal of Psychosomatic Research, 67 (1), pp. 37-43.

Objective To examine the relationship between cardiovascular activity in response to acute psychological stress and the antibody response to vaccination. Methods Fifty-seven healthy participants were vaccinated with the trivalent influenza vaccine and meningococcal A+C polysaccharides. Antibody levels were measured at baseline and 5-weeks post-vaccination. Cardiovascular activity was measured at rest, during, and following a mental arithmetic stress task in 54 participants. Results Participants demonstrating a fourfold increase in antibody titre to the A/Panama and B/Shangdong influenza strains and to meningococcal A showed greater blood pressure reactions toward the end of the acute stress task. In addition, there was some evidence of delayed diastolic blood pressure recovery in those who were responders to A/Panama and B/Shangdong influenza strains. Conclusion The present results suggest that heightened cardiovascular reactivity to stress and delayed recovery may not necessarily be detrimental to all aspects of health and may be associated with an enhanced immune response to antigen challenge.

Acute stress; Cardiovascular reactivity; Influenza vaccination; Meningococcal A+C vaccination

Journal of Psychosomatic Research: Volume 67, Issue 1

FundersUniversity of Birmingham
Publication date31/07/2009
Publication date online04/03/2009
Date accepted by journal02/12/2008
PublisherElsevier BV

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Professor Anna Whittaker

Professor Anna Whittaker

Professor of Behavioural Medicine, Sport