Altered human neutrophil function in response to acute psychological stress.



Khanfer R, Phillips AC, Carroll D & Lord J (2010) Altered human neutrophil function in response to acute psychological stress.. Psychosomatic Medicine, 72 (7), pp. 636-640.

Objective: To examine the effects of an acute laboratory psychological stress task on neutrophil function, specifically phagocytosis of Escherichia coli and stimulated superoxide production in human neutrophils. There is mounting evidence that acute stress is associated with short-term increases in a number of immune indices. Methods: Participants were 40 (n = 20 females) university students (mean age, 25.9 ± 4.56 years). Blood samples to determine neutrophil function by flow cytometry were taken at the end of resting baseline, during an acute stress task, and during recovery. The stress task was a 10-minute time-pressured mental arithmetic challenge with social evaluation. Results: There was an acute increase in phagocytic ability, p = .047, η2p = 0.076, and a reduction of superoxide production, p = .026, η2p = 0.101, associated with the stress task relative to baseline. Conclusion: These findings suggest that neutrophil bactericidal function may be sensitive to mental challenge tasks that provoke acute psychological stress. Further research is needed to replicate the observed psychological stress-induced changes in neutrophil function.

acute psychological stress; neutrophil; phagocytosis; superoxide production

Psychosomatic Medicine: Volume 72, Issue 7

FundersUniversity of Birmingham
Publication date30/09/2010
Publication date online31/07/2010
Date accepted by journal01/07/2010

People (1)


Professor Anna Whittaker

Professor Anna Whittaker

Professor of Behavioural Medicine, Sport