A statistical and biological response to an informatics appraisal of healthy aging gene signatures

Citation

Timmons JA, Gallagher IJ, Sood S, Phillips B, Crossland H, Howard R, Kraus WE & Atherton PJ (2019) A statistical and biological response to an informatics appraisal of healthy aging gene signatures. Genome Biology, 20 (1), Art. No.: 152. https://doi.org/10.1186/s13059-019-1734-z

Abstract
Jacob and Speed did not identify even a single example of a ‘150-gene-set’ that was statistically significant at classifying Alzheimer’s disease (AD) samples, or age in independent studies. We attempt to clarify the various misunderstandings.

Journal
Genome Biology: Volume 20, Issue 1