More miles on the clock: Neighbourhood stressors are associated with telomere length in a longitudinal study



Ellaway A, Dundas R, Robertson T & Shiels PG (2019) More miles on the clock: Neighbourhood stressors are associated with telomere length in a longitudinal study. PLOS ONE, 14 (3), Art. No.: e0214380.

Background There is a substantial gap in health and longevity between more affluent and more deprived areas, and more knowledge of the determinants of this health divide is required. Experience of the local residential environment is important for health although few studies have examined this in relation to biological markers of age such as telomere length. We sought to examine if residents’ perceptions of neighbourhood stressors over time were associated with telomere length in a community study. Methodology/Principal findings In a prospective cohort study of 2186 adults in the West of Scotland, we measured neighbourhood stressors at three time points over a 12-year period and telomere length at the end of the study. Using linear regression models, we found that a higher accumulation of neighbourhood stressors over time was associated with shorter telomere length, even after taking cohort, social class, health behaviours (smoking status, diet, physical activity), BMI and depression into account among females only (Beta = 0.007; 95%CI [0.001, 0.012]; P < 0.014). Conclusions/Significance Neighborhood environments are potentially modifiable, and future efforts directed towards improving deleterious local environments may be useful to lessen telomere attrition.

ageing; neighbourhoods; telomere; biomarkers; biosocial;

PLOS ONE: Volume 14, Issue 3

FundersMedical Research Council, Medical Research Council, Chief Scientist Office and Chief Scientist Office
Publication date28/03/2019
Publication date online28/03/2019
Date accepted by journal12/03/2019
PublisherPublic Library of Science (PLoS)

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Dr Tony Robertson
Dr Tony Robertson

Lecturer in Geographies of Public Health, Biological and Environmental Sciences


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