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Article

Editorial: quality of life and mortality in cirrhosis and ascites

Citation
O’Carroll R (2019) Editorial: quality of life and mortality in cirrhosis and ascites. Alimentary Pharmacology & Therapeutics, 49 (5), pp. 617-618. https://doi.org/10.1111/apt.15122

Abstract
First paragraph: MacDonald et al1 report an important study showing that health‐related quality of life (HRQL) predicted mortality in 405 patients with cirrhosis and severe ascites. HRQL was assessed using the SF‐36 which has two main subscales assessing physical (PCS) and mental (MCS) components. They found (a) patients with severe ascites reported poor HRQL (particularly PCS), (b) PCS was not correlated with traditional markers of liver disease and (c) after controlling for confounders, PCS (but not MCS) was a significant predictor of all‐cause and cirrhosis‐related death. While the presence of diuretic‐refractory ascites is known to be a predictor of mortality, HRQL is not a component of the current model for end‐stage liver disease (MELD).

Keywords
Pharmacology (medical)

Journal
Alimentary Pharmacology & Therapeutics: Volume 49, Issue 5

StatusPublished
Author(s)O’Carroll, Ronan
FundersNational Institute for Health Research and Chief Scientist Office
Publication date31/03/2019
Publication date online11/02/2019
Date accepted by journal11/02/2019
URLhttp://hdl.handle.net/1893/29126
PublisherWiley
ISSN0269-2813
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