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Article

Biomimetic oyster shell–replicated topography alters the behaviour of human skeletal stem cells

Citation
Waddell SJ, de Andrés MC, Tsimbouri PM, Alakpa EV, Cusack M, Dalby MJ & Oreffo ROC (2018) Biomimetic oyster shell–replicated topography alters the behaviour of human skeletal stem cells. Journal of Tissue Engineering, 9. https://doi.org/10.1177/2041731418794007

Abstract
The regenerative potential of skeletal stem cells provides an attractive prospect to generate bone tissue needed for musculoskeletal reparation. A central issue remains efficacious, controlled cell differentiation strategies to aid progression of cell therapies to the clinic. The nacre surface from Pinctada maxima shells is known to enhance bone formation. However, to date, there is a paucity of information on the role of the topography of P. maxima surfaces, nacre and prism. To investigate this, nacre and prism topographical features were replicated onto polycaprolactone and skeletal stem cell behaviour on the surfaces studied. Skeletal stem cells on nacre surfaces exhibited an increase in cell area, increase in expression of osteogenic markers ALP (p 

Keywords
Nacre; topography; skeletal stem cell; osteogenic differentiation; bone regeneration

Journal
Journal of Tissue Engineering: Volume 9

StatusPublished
Author(s)Waddell, Shona J; de Andrés, María C; Tsimbouri, Penelope M; Alakpa, Enateri V; Cusack, Maggie; Dalby, Matthew J; Oreffo, Richard O C
FundersMedical Research Council, Biotechnology and Biological Sciences Research Council, Biotechnology and Biological Sciences Research Council and UK Regenerative Medicine Platfrom
Publication date31/12/2018
Publication date online04/09/2018
Date accepted by journal19/07/2018
URLhttp://hdl.handle.net/1893/27956
PublisherSAGE Publications
ISSN2041-7314
eISSN2041-7314
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