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Article in Journal

Regenerative medicine: Stroke survivor and carer views and motivations towards a proposed stem cell clinical trial using placebo neurosurgery (Forthcoming/Available Online)

Citation
Cunningham N, Abhyankar P, Cowie J, Galinsky J & Methven K (2017) Regenerative medicine: Stroke survivor and carer views and motivations towards a proposed stem cell clinical trial using placebo neurosurgery (Forthcoming/Available Online), Health Expectations.

Abstract
Background 

Few studies explore stroke survivor views and motivations towards stem cell therapy (SCT). This qualitative study explores the views and motivations of both stroke survivors and their partners/carers towards a proposed 2-arm Phase III Randomised Controlled Trial (RCT) comparing intracerebral insertion of stem cells with placebo neurosurgery in stroke survivors with disability. 
Objective 
To explore views and motivations towards a proposed 2-arm stem cell trial and identify factors that may impede and enhance participation. 
Design 
This study adopts a naturalistic design to explore the complexity of this field, employing a participatory action-research approach comprising a specialized Conversation (World) Café form of focus group. Data were collected via 5 Conversation Cafés with stroke survivors (age 40-75) and partners/carers between June and October 2016. Of 66 participants, 53 (31 male, 22 female) were stroke survivors and 13 (6 female, 7 male) were partners/carers. Qualitative data were analysed using a thematic approach. 
Discussion and Conclusion 
Stroke survivor views and motivations reflect anticipation of the personal and future benefits of regenerative medicine. Partners/carers sought to balance the value of stroke survivor hope with carrying the weight of hope as carer, a conflict burden adding to known caregiver burden. All participants expressed the need for during and post-trial psychological support. This study provides a rare opportunity to explore the prospective views and motivations of stroke survivors and their partners/carers towards a proposed Phase III 2-arm RCT. This adds weight to qualitative evidence exploring capacity, consent, decision making, perceptions of treatment risk and supports required for clinical trial participation.

Keywords
caregiver burden; consent; regenerative medicine; treatment decision-making

StatusPublished
AuthorsCunningham Nicola, Abhyankar Purva, Cowie Julie, Galinsky Jayne, Methven Karen
Publication date online12/10/2017
Date accepted by journal11/09/2017
PublisherWiley-Blackwell
ISSN 1369-6513
LanguageEnglish

Journal
Health Expectations

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