Protein Deficiency, sacropenia and cardiometabolic risk in older urban black Cape Town populations: feasibility studies
PI: Dr Angus Hunter
Funded by: Medical Research Council
–
Contact details
- Email i.j.gallagher@stir.ac.uk
- Telephone+44 (0)1786 466024
- ORCID
0000-0002-8630-7235
About me
I completed my PhD in immunology at the University of Edinburgh (2006) before moving fields to work in transcriptomics and human physiology at Heriot-Watt University (2007). From there I moved to a post doctoral position in the Medical School of the University of Edinburgh (2009) where I continued research into human muscle pathology as well as developmental biology. I returned to Immunology with a post doctoral position at the Roslin Institute (2011) before taking up my current post at the University of Stirling. Follow me on twitter.
Education
The Regulation & Function of Fizz1 and Ym1 in Th2 Associated Inflammation
University of Edinburgh
Supervisors: Professor Judi Allen and Dr Ian Dransefield
MRes
University of Edinburgh
Research projects carried out in the areas of Developmental Biology, Genetics and Immunology.
Biomedical Science
Edinburgh Napier University
Honours modules in Toxicology, Immunology, Molecular Biology, Pathobiology and Human Physiology. Class Medal winner.
Event / Presentation
Invited Speaker - Transcriptomics in cancer cachexia
Invited talk on using transcriptomic studies in cancer cachexia.
Other Academic Activities
Grant reviewer for Doctor Hadwen Trust
Reviewer for PLoS Genetics
Professional membership
Associate Faculty Member of F1000 Prime
http://www.f1000.com/prime
F1000Prime (f1000.com/prime) is a post-publication peer review service that identifies and evaluates the top 2% of research in biology and medicine.
Member of Physiological Society
http://www.physoc.org/
Research
My research involves using high throughput technology to examine mRNA and microRNA changes in a variety of biological contexts spanning pathology, aeging, development and immunology. These projects involve microarray, RNA-sequencing, qRT-PCR, western blotting, cell culture and bioinfomatics. Collaborations include Professor James Timmons (Kings College London), Dr Janet Kung and Professors Kenneth Fearon and James Ross (Department of Clinical Surgery, University of Edinburgh) and Professors Olav Rooyackers and Thomas Gustafsson (Karolinska Institute).
Projects
Outputs
Article
Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing
Wilkinson DJ, Rodriguez-Blanco G, Dunn WB, Phillips BE, Williams JP, Greenhaff PL, Smith K, Gallagher IJ & Atherton PJ (2020) Untargeted metabolomics for uncovering biological markers of human skeletal muscle ageing. Aging. https://doi.org/10.18632/aging.103513
Article
Adipose depot gene expression and intelectin-1 in the metabolic response to cancer and cachexia
Miller J, Dreczkowski G, Ramage MI, Wigmore SJ, Gallagher IJ & Skipworth RJE (2020) Adipose depot gene expression and intelectin-1 in the metabolic response to cancer and cachexia. Journal of Cachexia, Sarcopenia and Muscle. https://doi.org/10.1002/jcsm.12568
Article
A statistical and biological response to an informatics appraisal of healthy aging gene signatures
Timmons JA, Gallagher IJ, Sood S, Phillips B, Crossland H, Howard R, Kraus WE & Atherton PJ (2019) A statistical and biological response to an informatics appraisal of healthy aging gene signatures. Genome Biology, 20 (1), Art. No.: 152. https://doi.org/10.1186/s13059-019-1734-z
Article
Ryde G, Dreczkowski G, Gallagher I, Chesham R & Gorely T (2019) Device-measured Desk-based Occupational Sitting Patterns and Stress (hair cortisol and perceived stress). International Journal of Environmental Research and Public Health, 16 (11), Art. No.: 1906. https://doi.org/10.3390/ijerph16111906
Article
The acute transcriptional response to resistance exercise: Impact of age and contraction mode
Deane CS, Ames RM, Phillips BE, Weedon MN, Willis CRG, Boereboom C, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, Smith K, Gallagher IJ, Kadi F & Szewczyk NJ (2019) The acute transcriptional response to resistance exercise: Impact of age and contraction mode. Aging, 11 (7), pp. 2111-2126. https://doi.org/10.18632/aging.101904
Article
A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease
Timmons JA, Atherton PJ, Larsson O, Sood S, Blokhin IO, Brogan RJ, Volmar C, Josse AR, Slentz C, Wahlestedt C, Phillips SM, Phillips BE, Gallagher IJ & Kraus WE (2018) A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease. Nucleic Acids Research, 46 (15), pp. 7772-7792. https://doi.org/10.1093/nar/gky570
Article
Jeromson S, Mackenzie I, Doherty MK, Whitfield PD, Bell JG, Dick JR, Shaw A, Rao F, Ashcroft SP, Philp A, Galloway SD, Gallagher IJ & Hamilton DL (2018) Lipid remodelling and an altered membrane-associated proteome may drive the differential effects of EPA and DHA treatment on skeletal muscle glucose uptake and protein accretion. American Journal of Physiology - Endocrinology and Metabolism, 314 (6), pp. E605-E619. https://doi.org/10.1152/ajpendo.00438.2015
Article
Assessing the Role of Muscle Protein Breakdown in Response to Nutrition and Exercise in Humans
Tipton KD, Hamilton DL & Gallagher IJ (2018) Assessing the Role of Muscle Protein Breakdown in Response to Nutrition and Exercise in Humans. Sports Medicine, 48 (S1), pp. 53-64. https://doi.org/10.1007/s40279-017-0845-5
Article
Multiple AMPK activators inhibit L-Carnitine uptake in C2C12 skeletal muscle myotubes
Shaw A, Jeromson S, Watterson KR, Pediani JD, Gallagher IJ, Whalley T, Dreczkowski G, Brooks N, Galloway SD & Hamilton DL (2017) Multiple AMPK activators inhibit L-Carnitine uptake in C2C12 skeletal muscle myotubes. American Journal of Physiology - Cell Physiology, 312 (6), pp. C689-C696. https://doi.org/10.1152/ajpcell.00026.2016
Article
Molecular studies of exercise, skeletal muscle, and ageing [version 1; referees: 2 approved]
Timmons JA & Gallagher IJ (2016) Molecular studies of exercise, skeletal muscle, and ageing [version 1; referees: 2 approved]. F1000Research, 5 (F1000 Faculty Rev), Art. No.: 1087. https://doi.org/10.12688/F1000RESEARCH.8255.1
Article
iGEMS: an integrated model for identification of alternative exon usage events
Sood S, Szkop KJ, Nakhuda A, Gallagher IJ, Murie C, Brogan RJ, Kaprio J, Kainulainen H, Atherton PJ, Kujala UM, Gustafsson T, Larsson O & Timmons JA (2016) iGEMS: an integrated model for identification of alternative exon usage events. Nucleic Acids Research, 44 (11), Art. No.: e109. https://doi.org/10.1093/nar/gkw263
Article
Omics/systems biology and cancer cachexia
Gallagher IJ, Jacobi C, Tardif N, Rooyackers O & Fearon KCH (2016) Omics/systems biology and cancer cachexia. Seminars in Cell and Developmental Biology, 54, pp. 92-103. https://doi.org/10.1016/j.semcdb.2015.12.022
Article
Jensen K, Gallagher IJ, Kaliszewska A, Zhang C, Abejide O, Gallagher MP, Werling D & Glass EJ (2016) Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells. Veterinary Research, 47, Art. No.: 46. https://doi.org/10.1186/s13567-016-0328-y
Article
Omega-3 Fatty Acids and Skeletal Muscle Health
Jeromson S, Gallagher IJ, Galloway SD & Hamilton DL (2015) Omega-3 Fatty Acids and Skeletal Muscle Health. Marine Drugs, 13 (11), pp. 6977-7004. https://doi.org/10.3390/md13116977
Article
A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status
Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJC, Lannfelt L, Kraus WE, Atherton PJ, Howard R, Gustafsson T, Hodges A & Timmons JA (2015) A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biology, 16 (1), Art. No.: 185. https://doi.org/10.1186/s13059-015-0750-x
Article
Multiple sources of bias confound functional enrichment analysis of global -omics data
Timmons JA, Szkop KJ & Gallagher IJ (2015) Multiple sources of bias confound functional enrichment analysis of global -omics data. Genome Biology, 16 (1), Art. No.: 186. https://doi.org/10.1186/s13059-015-0761-7
Article
Stephens N, Skipworth RJE, Gallagher IJ, Greig C, Guttridge DC, Ross JA & Fearon KCH (2015) Evaluating potential biomarkers of cachexia and survival in skeletal muscle of upper gastrointestinal cancer patients. Journal of Cachexia, Sarcopenia and Muscle, 6 (1), pp. 53-61. https://doi.org/10.1002/jcsm.12005
Article
Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation
Hamilton DL, Philp A, MacKenzie MG, Patton A, Towler MC, Gallagher IJ, Bodine SC & Baar K (2014) Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation. American Journal of Physiology - Endocrinology and Metabolism, 307 (4), pp. E365-E373. https://doi.org/10.1152/ajpendo.00674.2013
Article
Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing
Kilgour AHM, Gallagher IJ, MacLullich AMJ, Andrew R, Gray C, Hyde P, Wackerhage H, Husi H, Ross JA, Starr JM, Chapman KE, Fearon KCH, Walker BR & Greig C (2013) Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing. PLoS ONE, 8 (12), Art. No.: e84057. https://doi.org/10.1371/journal.pone.0084057
Article
Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL, Qi NR, Gustafsson T, Fielding RA, Timmons JA, Britton SL, Koch LG & Goodyear LJ (2013) Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes, 62 (8), pp. 2717-2727. https://doi.org/10.2337/db13-0062
Article
Ruckerl D, Jenkins SJ, Laqtom NN, Gallagher IJ, Sutherland TE, Duncan S, Buck AH & Allen JE (2012) Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo. Blood, 120 (11), pp. 2307-2316. https://doi.org/10.1182/blood-2012-02-408252
Article
Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function
Stephens N, Gray C, MacDonald A, Tan BH, Gallagher IJ, Skipworth RJE, Ross JA, Fearon KCH & Greig C (2012) Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function. Clinical Nutrition, 31 (4), pp. 499-505. https://doi.org/10.1016/j.clnu.2011.12.008
Article
Gallagher IJ, Stephens N, MacDonald A, Skipworth RJE, Husi H, Greig C, Ross JA, Timmons JA & Fearon KCH (2012) Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies. Clinical Cancer Research, 18 (10), pp. 2817-2827. https://doi.org/10.1158/1078-0432.CCR-11-2133
Article
Proteomic analysis of urinary upper gastrointestinal cancer markers
Husi H, Stephens N, Cronshaw A, MacDonald A, Gallagher IJ, Greig C, Fearon KCH & Ross JA (2011) Proteomic analysis of urinary upper gastrointestinal cancer markers. PROTEOMICS - Clinical Applications, 5 (5-6), pp. 289-299. https://doi.org/10.1002/prca.201000107
Article
Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity
Keller P, Gburcik V, Petrovic N, Gallagher IJ, Nedergaard J, Cannon B & Timmons JA (2011) Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity. BMC Endocrine Disorders, 11 (7). https://doi.org/10.1186/1472-6823-11-7
Article
Davidsen PK, Gallagher IJ, Hartman JW, Tarnopolsky MA, Dela F, Helge JW, Timmons JA & Phillips SM (2011) High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression. Journal of Applied Physiology, 110 (2), pp. 309-17. https://doi.org/10.1152/japplphysiol.00901.2010
Article
A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype
Keller P, Vollaard N, Gustafsson T, Gallagher IJ, Sundberg CJ, Rankinen T, Britton SL, Bouchard C, Koch LG & Timmons JA (2011) A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. Journal of Applied Physiology, 110 (1), pp. 46-59. https://doi.org/10.1152/japplphysiol.00634.2010
Article
Gallagher IJ, Scheele C, Keller P, Nielsen AR, Remenyi J, Fischer CP, Roder K, Babraj J, Wahlestedt C, Hutvagner G, Pedersen BK & Timmons JA (2010) Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Medicine, 2 (9), p. 9. https://doi.org/10.1186/gm130
Article
Stephens N, Gallagher IJ, Rooyackers O, Skipworth RJE, Tan BH, Marstrand T, Ross JA, Guttridge DC, Lundell L, Fearon KCH & Timmons JA (2010) Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia. Genome Medicine, 2 (1). https://doi.org/10.1186/gm122
Article
Attout T, Martin C, Babayan SA, Kozek WJ, Bazzocchi C, Oudet F, Gallagher IJ, Specht S & Bain O (2008) Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain. Parasitology International, 57 (2), pp. 201-211. https://doi.org/10.1016/j.parint.2008.01.001
Article
Loke P, Gallagher IJ, Nair MG, Zang X, Brombacher F, Mohrs M, Allison JP & Allen JE (2007) Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. Journal of Immunology, 179 (6), pp. 3926-3936. http://www.jimmunol.org/content/179/6/3926.abstract
Article
Arora M, Chen L, Paglia M, Gallagher IJ, Allen JE, Vyas YM, Ray A & Ray P (2006) Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. Proceedings of the National Academy of Sciences, 103 (20), pp. 7777-7782. https://doi.org/10.1073/pnas.0508492103
Article
Nair MG, Gallagher IJ, Taylor M, Loke P, Coulson PS, Wilson RA, Maizels RM & Allen JE (2005) Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells. Infection and Immunity, 73 (1), pp. 385-394. https://doi.org/10.1128/IAI.73.1.385-394.2005
