Dr Iain Gallagher

Lecturer in Health & Exercise

Sport University of Stirling, Stirling, FK9 4LA

Contact details

Email i.j.gallagher@stir.ac.uk
Telephone+44 (0)1786 466024

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About me

I completed my PhD in immunology at the University of Edinburgh (2006) before moving fields to work in transcriptomics and human physiology at Heriot-Watt University (2007). From there I moved to a post doctoral position in the Medical School of the University of Edinburgh (2009) where I continued research into human muscle pathology as well as developmental biology. I returned to Immunology with a post doctoral position at the Roslin Institute (2011) before taking up my current post at the University of Stirling. Follow me on twitter.

Education

The Regulation & Function of Fizz1 and Ym1 in Th2 Associated Inflammation
University of Edinburgh
2006
Supervisors: Professor Judi Allen and Dr Ian Dransefield

MRes
University of Edinburgh
2002
Research projects carried out in the areas of Developmental Biology, Genetics and Immunology.

Biomedical Science
Edinburgh Napier University
2000
Honours modules in Toxicology, Immunology, Molecular Biology, Pathobiology and Human Physiology. Class Medal winner.

Event / Presentation

Invited Speaker - Transcriptomics in cancer cachexia
2018
Invited talk on using transcriptomic studies in cancer cachexia.

Other Academic Activities

Grant reviewer for Doctor Hadwen Trust

Reviewer for PLoS Genetics

Professional membership

Associate Faculty Member of F1000 Prime
http://www.f1000.com/prime
F1000Prime (f1000.com/prime) is a post-publication peer review service that identifies and evaluates the top 2% of research in biology and medicine.

Member of Physiological Society
http://www.physoc.org/

Research

My research involves using high throughput technology to examine mRNA and microRNA changes in a variety of biological contexts spanning pathology, aeging, development and immunology. These projects involve microarray, RNA-sequencing, qRT-PCR, western blotting, cell culture and bioinfomatics. Collaborations include Professor James Timmons (Kings College London), Dr Janet Kung and Professors Kenneth Fearon and James Ross (Department of Clinical Surgery, University of Edinburgh) and Professors Olav Rooyackers and Thomas Gustafsson (Karolinska Institute).

Projects

Protein Deficiency, sacropenia and cardiometabolic risk in older urban black Cape Town populations: feasibility studies
PI: Dr Angus Hunter
Funded by: Medical Research Council
01/03/2018–15/10/2019

Outputs

Article

A statistical and biological response to an informatics appraisal of healthy aging gene signatures

Timmons JA, Gallagher IJ, Sood S, Phillips B, Crossland H, Howard R, Kraus WE & Atherton PJ (2019) A statistical and biological response to an informatics appraisal of healthy aging gene signatures. Genome Biology, 20 (1), Art. No.: 152. https://doi.org/10.1186/s13059-019-1734-z

Article

Device-measured Desk-based Occupational Sitting Patterns and Stress (hair cortisol and perceived stress)

Ryde G, Dreczkowski G, Gallagher I, Chesham R & Gorely T (2019) Device-measured Desk-based Occupational Sitting Patterns and Stress (hair cortisol and perceived stress). International Journal of Environmental Research and Public Health, 16 (11), Art. No.: 1906. https://doi.org/10.3390/ijerph16111906

Article

The acute transcriptional response to resistance exercise: Impact of age and contraction mode

Deane CS, Ames RM, Phillips BE, Weedon MN, Willis CRG, Boereboom C, Abdulla H, Bukhari SSI, Lund JN, Williams JP, Wilkinson DJ, Smith K, Gallagher IJ, Kadi F & Szewczyk NJ (2019) The acute transcriptional response to resistance exercise: Impact of age and contraction mode. Aging, 11 (7), pp. 2111-2126. https://doi.org/10.18632/aging.101904

Article

A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease

Timmons JA, Atherton PJ, Larsson O, Sood S, Blokhin IO, Brogan RJ, Volmar C, Josse AR, Slentz C, Wahlestedt C, Phillips SM, Phillips BE, Gallagher IJ & Kraus WE (2018) A coding and non-coding transcriptomic perspective on the genomics of human metabolic disease. Nucleic Acids Research, 46 (15), pp. 7772-7792. https://doi.org/10.1093/nar/gky570

Article

Lipid remodelling and an altered membrane-associated proteome may drive the differential effects of EPA and DHA treatment on skeletal muscle glucose uptake and protein accretion

Jeromson S, Mackenzie I, Doherty MK, Whitfield PD, Bell JG, Dick JR, Shaw A, Rao F, Ashcroft SP, Philp A, Galloway SD, Gallagher IJ & Hamilton DL (2018) Lipid remodelling and an altered membrane-associated proteome may drive the differential effects of EPA and DHA treatment on skeletal muscle glucose uptake and protein accretion. American Journal of Physiology - Endocrinology and Metabolism, 314 (6), pp. E605-E619. https://doi.org/10.1152/ajpendo.00438.2015

Article

Assessing the Role of Muscle Protein Breakdown in Response to Nutrition and Exercise in Humans

Tipton KD, Hamilton DL & Gallagher IJ (2018) Assessing the Role of Muscle Protein Breakdown in Response to Nutrition and Exercise in Humans. Sports Medicine, 48 (S1), pp. 53-64. https://doi.org/10.1007/s40279-017-0845-5

Article

Multiple AMPK activators inhibit L-Carnitine uptake in C2C12 skeletal muscle myotubes

Shaw A, Jeromson S, Watterson KR, Pediani JD, Gallagher IJ, Whalley T, Dreczkowski G, Brooks N, Galloway SD & Hamilton DL (2017) Multiple AMPK activators inhibit L-Carnitine uptake in C2C12 skeletal muscle myotubes. American Journal of Physiology - Cell Physiology, 312 (6), pp. C689-C696. https://doi.org/10.1152/ajpcell.00026.2016

Article

Omics/systems biology and cancer cachexia

Gallagher IJ, Jacobi C, Tardif N, Rooyackers O & Fearon KCH (2016) Omics/systems biology and cancer cachexia. Seminars in Cell and Developmental Biology, 54, pp. 92-103. https://doi.org/10.1016/j.semcdb.2015.12.022

Article

iGEMS: an integrated model for identification of alternative exon usage events

Sood S, Szkop KJ, Nakhuda A, Gallagher IJ, Murie C, Brogan RJ, Kaprio J, Kainulainen H, Atherton PJ, Kujala UM, Gustafsson T, Larsson O & Timmons JA (2016) iGEMS: an integrated model for identification of alternative exon usage events. Nucleic Acids Research, 44 (11), Art. No.: e109. https://doi.org/10.1093/nar/gkw263

Article

Molecular studies of exercise, skeletal muscle, and ageing [version 1; referees: 2 approved]

Timmons JA & Gallagher IJ (2016) Molecular studies of exercise, skeletal muscle, and ageing [version 1; referees: 2 approved]. F1000Research, 5 (F1000 Faculty Rev), Art. No.: 1087. https://doi.org/10.12688/F1000RESEARCH.8255.1

Article

Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells

Jensen K, Gallagher IJ, Kaliszewska A, Zhang C, Abejide O, Gallagher MP, Werling D & Glass EJ (2016) Live and inactivated Salmonella enterica serovar Typhimurium stimulate similar but distinct transcriptome profiles in bovine macrophages and dendritic cells. Veterinary Research, 47, Art. No.: 46. https://doi.org/10.1186/s13567-016-0328-y

Article

Omega-3 Fatty Acids and Skeletal Muscle Health

Jeromson S, Gallagher IJ, Galloway SD & Hamilton DL (2015) Omega-3 Fatty Acids and Skeletal Muscle Health. Marine Drugs, 13 (11), pp. 6977-7004. https://doi.org/10.3390/md13116977

Article

A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status

Sood S, Gallagher IJ, Lunnon K, Rullman E, Keohane A, Crossland H, Phillips BE, Cederholm T, Jensen T, van Loon LJC, Lannfelt L, Kraus WE, Atherton PJ, Howard R, Gustafsson T, Hodges A & Timmons JA (2015) A novel multi-tissue RNA diagnostic of healthy ageing relates to cognitive health status. Genome Biology, 16 (1), Art. No.: 185. https://doi.org/10.1186/s13059-015-0750-x

Article

Multiple sources of bias confound functional enrichment analysis of global -omics data

Timmons JA, Szkop KJ & Gallagher IJ (2015) Multiple sources of bias confound functional enrichment analysis of global -omics data. Genome Biology, 16 (1), Art. No.: 186. https://doi.org/10.1186/s13059-015-0761-7

Article

Evaluating potential biomarkers of cachexia and survival in skeletal muscle of upper gastrointestinal cancer patients

Stephens N, Skipworth RJE, Gallagher IJ, Greig C, Guttridge DC, Ross JA & Fearon KCH (2015) Evaluating potential biomarkers of cachexia and survival in skeletal muscle of upper gastrointestinal cancer patients. Journal of Cachexia, Sarcopenia and Muscle, 6 (1), pp. 53-61. https://doi.org/10.1002/jcsm.12005

Article

Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation

Hamilton DL, Philp A, MacKenzie MG, Patton A, Towler MC, Gallagher IJ, Bodine SC & Baar K (2014) Molecular brakes regulating mTORC1 activation in skeletal muscle following synergist ablation. American Journal of Physiology - Endocrinology and Metabolism, 307 (4), pp. E365-E373. https://doi.org/10.1152/ajpendo.00674.2013

Article

Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing

Kilgour AHM, Gallagher IJ, MacLullich AMJ, Andrew R, Gray C, Hyde P, Wackerhage H, Husi H, Ross JA, Starr JM, Chapman KE, Fearon KCH, Walker BR & Greig C (2013) Increased skeletal muscle 11βHSD1 mRNA is associated with lower muscle strength in ageing. PLoS ONE, 8 (12), Art. No.: e84057. https://doi.org/10.1371/journal.pone.0084057

Article

Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks

Lessard SJ, Rivas DA, Alves-Wagner AB, Hirshman MF, Gallagher IJ, Constantin-Teodosiu D, Atkins R, Greenhaff PL, Qi NR, Gustafsson T, Fielding RA, Timmons JA, Britton SL, Koch LG & Goodyear LJ (2013) Resistance to aerobic exercise training causes metabolic dysfunction and reveals novel exercise-regulated signaling networks. Diabetes, 62 (8), pp. 2717-2727. https://doi.org/10.2337/db13-0062

Article

Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo

Ruckerl D, Jenkins SJ, Laqtom NN, Gallagher IJ, Sutherland TE, Duncan S, Buck AH & Allen JE (2012) Induction of IL-4Rα-dependent microRNAs identifies PI3K/Akt signaling as essential for IL-4-driven murine macrophage proliferation in vivo. Blood, 120 (11), pp. 2307-2316. https://doi.org/10.1182/blood-2012-02-408252

Article

Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function

Stephens N, Gray C, MacDonald A, Tan BH, Gallagher IJ, Skipworth RJE, Ross JA, Fearon KCH & Greig C (2012) Sexual dimorphism modulates the impact of cancer cachexia on lower limb muscle mass and function. Clinical Nutrition, 31 (4), pp. 499-505. https://doi.org/10.1016/j.clnu.2011.12.008

Article

Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies

Gallagher IJ, Stephens N, MacDonald A, Skipworth RJE, Husi H, Greig C, Ross JA, Timmons JA & Fearon KCH (2012) Suppression of skeletal muscle turnover in cancer cachexia: evidence from the transcriptome in sequential human muscle biopsies. Clinical Cancer Research, 18 (10), pp. 2817-2827. https://doi.org/10.1158/1078-0432.CCR-11-2133

Article

Proteomic analysis of urinary upper gastrointestinal cancer markers

Husi H, Stephens N, Cronshaw A, MacDonald A, Gallagher IJ, Greig C, Fearon KCH & Ross JA (2011) Proteomic analysis of urinary upper gastrointestinal cancer markers. PROTEOMICS - Clinical Applications, 5 (5-6), pp. 289-299. https://doi.org/10.1002/prca.201000107

Article

Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity

Keller P, Gburcik V, Petrovic N, Gallagher IJ, Nedergaard J, Cannon B & Timmons JA (2011) Gene-chip studies of adipogenesis-regulated microRNAs in mouse primary adipocytes and human obesity. BMC Endocrine Disorders, 11 (7). https://doi.org/10.1186/1472-6823-11-7

Article

High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression

Davidsen PK, Gallagher IJ, Hartman JW, Tarnopolsky MA, Dela F, Helge JW, Timmons JA & Phillips SM (2011) High responders to resistance exercise training demonstrate differential regulation of skeletal muscle microRNA expression. Journal of Applied Physiology, 110 (2), pp. 309-17. https://doi.org/10.1152/japplphysiol.00901.2010

Article

A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype

Keller P, Vollaard N, Gustafsson T, Gallagher IJ, Sundberg CJ, Rankinen T, Britton SL, Bouchard C, Koch LG & Timmons JA (2011) A transcriptional map of the impact of endurance exercise training on skeletal muscle phenotype. Journal of Applied Physiology, 110 (1), pp. 46-59. https://doi.org/10.1152/japplphysiol.00634.2010

Article

Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes

Gallagher IJ, Scheele C, Keller P, Nielsen AR, Remenyi J, Fischer CP, Roder K, Babraj J, Wahlestedt C, Hutvagner G, Pedersen BK & Timmons JA (2010) Integration of microRNA changes in vivo identifies novel molecular features of muscle insulin resistance in type 2 diabetes. Genome Medicine, 2 (9), p. 9. https://doi.org/10.1186/gm130

Article

Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia

Stephens N, Gallagher IJ, Rooyackers O, Skipworth RJE, Tan BH, Marstrand T, Ross JA, Guttridge DC, Lundell L, Fearon KCH & Timmons JA (2010) Using transcriptomics to identify and validate novel biomarkers of human skeletal muscle cancer cachexia. Genome Medicine, 2 (1). https://doi.org/10.1186/gm122

Article

Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain

Attout T, Martin C, Babayan SA, Kozek WJ, Bazzocchi C, Oudet F, Gallagher IJ, Specht S & Bain O (2008) Pleural cellular reaction to the filarial infection Litomosoides sigmodontis is determined by the moulting process, the worm alteration, and the host strain. Parasitology International, 57 (2), pp. 201-211. https://doi.org/10.1016/j.parint.2008.01.001

Article

Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection

Loke P, Gallagher IJ, Nair MG, Zang X, Brombacher F, Mohrs M, Allison JP & Allen JE (2007) Alternative activation is an innate response to injury that requires CD4+ T cells to be sustained during chronic infection. Journal of Immunology, 179 (6), pp. 3926-3936. http://www.jimmunol.org/content/179/6/3926.abstract

Article

Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells

Arora M, Chen L, Paglia M, Gallagher IJ, Allen JE, Vyas YM, Ray A & Ray P (2006) Simvastatin promotes Th2-type responses through the induction of the chitinase family member Ym1 in dendritic cells. Proceedings of the National Academy of Sciences, 103 (20), pp. 7777-7782. https://doi.org/10.1073/pnas.0508492103

Article

Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells

Nair MG, Gallagher IJ, Taylor M, Loke P, Coulson PS, Wilson RA, Maizels RM & Allen JE (2005) Chitinase and Fizz family members are a generalized feature of nematode infection with selective upregulation of Ym1 and Fizz1 by antigen-presenting cells. Infection and Immunity, 73 (1), pp. 385-394. https://doi.org/10.1128/IAI.73.1.385-394.2005