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A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation

Citation
McMahon A, Evans J, White G, Murray FE, McGilchrist MM, McDevitt DG & MacDonald TM (1997) A cohort study (with re-sampled comparator groups) to measure the association between new NSAID prescribing and upper gastrointestinal hemorrhage and perforation, Journal of Clinical Epidemiology, 50 (3), pp. 351-356.

Abstract
This cohort study examined the relationship between newly prescribed NSAIDs (none in the previous six months) and upper gastrointestinal hemorrhage and perforation in Tayside, Scotland. Exposure was classified by prescription duration. The study population consisted of the population of Tayside. A Comparator Group was chosen at random (within age and sex strata). Two hundred re-sampled comparator groups were created. Statistical analyses were carried out by Poisson regression (repeated for each of the re-samples). The analyses controlled for age, sex, prior hospitalization for upper gastrointestinal events, prior endoscopy, and the use of ulcer healing drugs. There were 78,191 subjects in the NSAID group, and 78,207 in each of the comparator groups. The increased risk with NSAIDs was only apparent for subjects without a history of upper gastrointestinal events; univariate rate ratio = 2.76 (1.90, 4.01). The final, re-sampled estimate of NSAID risk was rate ratio = 2.48 (1.87, 3.29).

Keywords
Cohort; Epidemiology; Re-sampling; NSAID; Hemorrhage; Perforation

StatusPublished
AuthorsMcMahon Alex, Evans Josie, White G, Murray Frank E, McGilchrist Mark M, McDevitt Denis G, MacDonald Thomas M
Publication date03/1997
Publication date online15/12/1997
PublisherElsevier
ISSN 0895-4356
LanguageEnglish

Journal
Journal of Clinical Epidemiology: Volume 50, Issue 3 (MAR 1997)

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