Research output

Article in Journal ()

Mixed blocked/event-related designs separate transient and sustained activity in fMRI

Citation
Visscher KM, Miezin FM, Kelly JE, Buckner R, Donaldson D, McAvoy MP, Bhalodia VM & Petersen SE (2003) Mixed blocked/event-related designs separate transient and sustained activity in fMRI, NeuroImage, 19 (4), pp. 1694-1708.

Abstract
Recent functional magnetic resonance imaging (fMRI) studies using mixed blocked/event-related designs have shown activity consistent with separable sustained task-related processes and transient trial-related processes. In the mixed design, control blocks are intermixed with task blocks, during which trials are presented at varying intervals. Two studies were conducted to assess the ability of this design to detect and dissociate sustained task-related from transient trial-related activity. Analyses on both simulated and empirical data were performed by using the general linear model with a shape assumed for sustained effects, but not transient effects. In the first study, simulated data were produced with sustained time courses, transient time courses, and the sum of both together. Analyses of these data showed appropriate parsing of sustained and transient activity in all three cases. For the empirical fMRI experiment, counterphase-flickering checkerboard stimuli were constructed to produce sustained, transient, and combined sustained and transient responses in visual cortex. As with the simulation, appropriate parsing of sustained and transient activity was seen in all three cases; i.e., sustained stimuli produced sustained time courses and transient stimuli produced transient time courses. Combined stimuli produced both transient and sustained time courses. Critically, transient stimuli alone did not produce spurious positive sustained responses; sustained stimuli alone produced negligible spurious transient time courses. The results of these two studies along with supplemental simulations provide strong evidence that mixed designs are an effective tool for separating transient, trial-related activity from sustained activity in fMRI experiments. Mixed designs can allow researchers a means to examine brain activity associated with sustained processes, potentially related to task-level control signals.

StatusPublished
AuthorsVisscher Kristina M, Miezin Francis M, Kelly James E, Buckner Randy, Donaldson David, McAvoy Mark P, Bhalodia Vidya M, Petersen Steve E
Publication date08/2003
PublisherElsevier
ISSN 1053-8119
LanguageEnglish

Journal
Neuroimage: Volume 19, Issue 4 (AUG 2003)

© University of Stirling FK9 4LA Scotland UK • Telephone +44 1786 473171 • Scottish Charity No SC011159
My Portal