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Induction of piscine metallothionein as a primary response to heavy metal pollutants: applicability of new sensitive molecular probes

Citation
Kille P, Kay J, Leaver M & George S (1992) Induction of piscine metallothionein as a primary response to heavy metal pollutants: applicability of new sensitive molecular probes, Aquatic Toxicology, 22 (4), pp. 279-286.

Abstract
Induction of metallothionein (MT) in piscine tissues is a primary response to heavy metals which is now being utilised for environmental monitoring. Recent molecular biological and immunological studies have revealed a strong structural conservation amongst fish MTs and clear differences from their mammalian and avian orthologues. Probes derived from these studies are now being utilised to investigate the functional role of MT in metal regulation and cytotoxicity.

Keywords
Fish metallothioneins; mRNA; Amino acid sequences; Immunoassay; Cuitured cells; Heavy metals; Hormones

StatusPublished
AuthorsKille Peter, Kay John, Leaver Michael, George Stephen
Publication date06/1992
Publication date online07/11/2002
URLhttp://www.sciencedirect.com/…0166445X9290045O
PublisherElsevier
ISSN 0166-445X
LanguageEnglish

Journal
Aquatic Toxicology: Volume 22, Issue 4 (JUN 1992)

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