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Primitive neuroectodermal tumour in a striped dolphin (Stenella coeruleoalba) with features of ependymoma and neural tube differentiation (Medulloepithelioma)

Citation
Baily J, Morrison LR, Patterson IA, Underwood C & Dagleish MP (2013) Primitive neuroectodermal tumour in a striped dolphin (Stenella coeruleoalba) with features of ependymoma and neural tube differentiation (Medulloepithelioma), Journal of Comparative Pathology, 149 (4), pp. 514-519.

Abstract
Primary brain tumours in cetaceans are rare with only four reported cases of intracranial tumours in the scientific literature. A juvenile female, striped dolphin live-stranded at Whitepark Bay, Co Antrim, Northern Ireland, UK, and died after an unsuccessful attempt at refloatation. Necropsy examination revealed a large, soft, non-encapsulated friable mass, which expanded and replaced the frontal lobes, corpus callosum and caudate nucleus of the brain and extended into the lateral ventricles, displacing the thalamus caudally. Microscopically, this comprised moderately pleomorphic neoplastic cells arranged variably in dense monotonous sheets, irregular streams, ependymal rosettes, ‘ependymoblastomatous rosettes’ and multilayered to pseudostratified tubules. Liquefactive necrosis, palisading glial cells, haemorrhage and mineralization were also observed. Immunohistochemically, the neoplastic cells expressed vimentin but not S100, glial fibrillary acidic protein, cytokeratin, neuron-specific enolase or synaptophysin. Based on these findings a diagnosis of primitive neuroectodermal tumour was made. Monitoring and recording such cases is crucial as neoplasia may be related to viral, carcinogenic or immunosuppressive chemical exposure and can ultimately contribute to assessing the ocean health.

Keywords
central nervous system; neoplasia; primitive neuroectodermal tumour; Stenella coeruleoalba

StatusPublished
AuthorsBaily Johanna, Morrison Linda R, Patterson I A, Underwood Clare, Dagleish Mark P
Publication date11/2013
Publication date online06/09/2013
Date accepted by journal14/06/2013
PublisherElsevier
ISSN 0021-9975
LanguageEnglish

Journal
Journal of Comparative Pathology: Volume 149, Issue 4

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