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Inhibitory control of site-specific synaptic plasticity in a model CA1 pyramidal neuron

Citation
Saudargiene A & Graham B (2015) Inhibitory control of site-specific synaptic plasticity in a model CA1 pyramidal neuron, Biosystems, 130, pp. 37-50.

Abstract
A computational model of a biochemical network underlying synaptic plasticity is combined with simulated on-going electrical activity in a model of a hippocampal pyramidal neuron to study the impact of synapse location and inhibition on synaptic plasticity. The simulated pyramidal neuron is activated by the realistic stimulation protocol of causal and anticausal spike pairings of presynaptic and postsynaptic action potentials in the presence and absence of spatially targeted inhibition provided by basket, bistratified and oriens-lacunosum moleculare (OLM) interneurons. The resulting Spike-timing-dependent plasticity (STDP) curves depend strongly on the number of pairing repetitions, the synapse location and the timing and strength of inhibition.

Keywords
Spike-timing-dependent plasticity; CA1 pyramidal neuron; Dendritic spike; Inhibitory interneurons

StatusPublished
AuthorsSaudargiene Ausra, Graham Bruce
Publication date04/2015
Publication date online10/03/2015
Date accepted by journal06/03/2015
PublisherElsevier
ISSN 0303-2647
LanguageEnglish

Journal
Biosystems: Volume 130 (2015)

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