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Article in Journal ()

Broadwick: a framework for computational epidemiology

Citation
O'Hare A, Lycett SJ, Doherty T, Salvador LCM & Kao RR (2016) Broadwick: a framework for computational epidemiology, BMC Bioinformatics, 17 (1), Art. No.: 65.

Abstract
Background 

Modelling disease outbreaks often involves integrating the wealth of data that are gathered during modern outbreaks into complex mathematical or computational models of transmission. Incorporating these data into simple compartmental epidemiological models is often challenging, requiring the use of more complex but also more efficient computational models. In this paper we introduce a new framework that allows for a more systematic and user-friendly way of building and running epidemiological models that efficiently handles disease data and reduces much of the boilerplate code that usually associated to these models. We introduce the framework by developing an SIR model on a simple network as an example. 
Results 
We develop Broadwick, a modular, object-oriented epidemiological framework that efficiently handles large epidemiological datasets and provides packages for stochastic simulations, parameter inference using Approximate Bayesian Computation (ABC) and Markov Chain Monte Carlo (MCMC) methods. Each algorithm used is fully customisable with sensible defaults that are easily overridden by custom algorithms as required. 
Conclusion 
Broadwick is an epidemiological modelling framework developed to increase the productivity of researchers by providing a common framework with which to develop and share complex models. It will appeal to research team leaders as it allows for models to be created prior to a disease outbreak and has the ability to handle large datasets commonly found in epidemiological modelling.

Keywords
Epidemiology; Modelling; Framework; Modularity

StatusPublished
AuthorsO'Hare Anthony, Lycett Samantha J, Doherty Thomas, Salvador Liliana C M, Kao Rowland R
Publication date04/02/2016
Publication date online04/02/2016
Date accepted by journal21/01/2016
PublisherBioMed Central
ISSN 1471-2105
LanguageEnglish

Journal
bmc Bioinformatics: Volume 17, Issue 1 (2016DA - 2016//)

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