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Mixture toxicity effects of sea louse control agents in Daphnia magna

Citation
Rose S, Altenburger R & Sturm A (2016) Mixture toxicity effects of sea louse control agents in Daphnia magna, Chemosphere, 144, pp. 599-606.

Abstract
Caligid sea lice are ectoparasites causing major disease problems in industrial salmon farming. Sea louse control currently relies widely on parasiticides. Among non-target species, crustaceans are particularly susceptible to salmon delousing agents. Drug combinations have recently been suggested for sea louse control; however, no information is available on the non-target effects of such mixtures. To obtain first insights into combination effects of salmon parasiticides, acute toxicity tests with the crustacean model speciesDaphnia magnawere conducted. Four compounds, including two organophosphates and two pyrethroids, were tested individually and in all pair-wise combinations at one fixed concentration ratio. For most combinations, observed toxicities were close to predictions assuming concentration additivity. However, deltamethrin and cypermethrin showed greater than predicted combination effects, while the inverse was observed for deltamethrin and malathion. The results demonstrate combination effects of anti-sea louse agents and suggest that predictions based on concentration additivity are in most cases protective.

Keywords
Biocide; Mixture toxicity; Aquaculture; Parasite; Veterinary; Drug

StatusPublished
AuthorsRose Stephanie, Altenburger Rolf, Sturm Armin
Publication date02/2016
Publication date online21/09/2015
Date accepted by journal14/08/2015
PublisherElsevier
ISSN 0045-6535
LanguageEnglish

Journal
Chemosphere: Volume 144

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